Mag 4-aminopyridine vervangen worden door 3,4-aminopyridine?

4-aminopyridine en 3,4-aminopyridine zijn niet identiek. De Martindale geeft volgende informatie: “4-aminopyridine or fampridine enhances the release of acetylcholine from nerve terminals and has been used intravenously to reverse the effects of competitive neuromuscular blockers. It has also been tried orally and intravenously in the management of neurological disorders such as Eaton-Lambert myasthenic syndrome Guillain- Barré syndrome , multiple sclerosis , spinal cord injury, and Alzheimer’s disease , and for the reversal of neuromuscular blockade in patients with botulism.
3,4-aminopyridine or amifampridine has similar actions and uses to fampridine but is reported to be more potent in enhancing the release of acetylcholine from nerve terminals. It is used in the Eaton-Lambert myasthenic syndrome (below) and other myasthenic conditions. It has been tried in multiple sclerosis and in botulism. There have been isolated reports of seizures and amifampridine is therefore contra-indicated in patients with epilepsy.”